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KMID : 0381120200420020203
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Genes and Genomics
2020 Volume.42 No. 2 p.203 ~ p.215
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Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed
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Moradian Hasan
Koshkoiyeh Ali Esmailizadeh
Mohammadabadi Mohammadreza
Fozi Masood Asadi
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Abstract
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Background: The identification of genomic regions under selection can potentially permit a better understanding of the biology of the specific phenotypes which are useful for the development of tools designed to increase selection efficiency.
Objective: The aim of this study was to detect any traces of recent selection signatures as well as to identify corresponding genes and QTLs underlying these selection signatures in Sarabi cattle.
Methods: Samples from 20 animals were genotyped for 777,962 SNPs across the genome using the Illumina BovineHD BeadChip. Selection signatures analysis was performed using the integrated haplotype score (iHS) methodology.
Results: A total of eight significant regions (P?
Conclusion: The results revealed multiple genomic regions as well as multiple new genes under positive selection on BTA14 and BTA17. Moreover, candidate selected regions that overlap with QTL reported in the cattle QTL database provided additional evidence for the significance of the detected regions under selection. This study provides a foundation for detailed analysis of the identified putative selection signatures in the cattle genome particularly of the indigenous and locally-developed cattle breeds and provides an avenue for a well-structured breed improvement.
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